20 faculty and 45 courses in Biochemistry at Case Western Reserve University.
- Christopher Hubert, Faculty h-index 94
Brain tumors can be among the most lethal cancers known, and are now the most frequent cause of cancer death in adolescents and young adults. Advanced brain tumors are driven by cancer stem cells and have extreme cellular diversity, with di
Notable: “admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties” (2012) · 2,217 citations
- J. Alan Diehl, Faculty h-index 87
Dr. Diehl’s research focuses on the molecular mechanisms of cancer initiation and progression with specific focus on the regulation of cell division and post-translational in cancer. The Diehl lab also explores the interconnections of lipid
Notable: “Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization” (1998) · 2,115 citations
- Xin Liu, Faculty h-index 52
My lab is interested in understanding how the immune system responds to a variety of insults (e.g. bacteria, viruses, tumors) to control human diseases (e.g. infectious diseases and cancer). Increasing evidence has implicated that metabolis
Notable: “New World Bats Harbor Diverse Influenza A Viruses” (2013) · 1,356 citations
- Tae Hun Kim, Faculty h-index 50
Human cells store approximately 3 billion base pairs of DNA in the nucleus, which would be roughly 2 meters long if fully extended. However, the DNA is contained within the nucleus, which is only around 6 μm in diameter, due to compaction b
Notable: “Chemical modification of chitosan as a gene carrier in vitro and in vivo” (2007) · 321 citations
- Xiao Li, Faculty h-index 46
Human diseases are caused by the interplay between gene and environment. Deep sequencing reveals millions of mutations between the genomes of unrelated individuals; however, the consequences of these mutations remain mostly unclear. B
Notable: “Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling” (2005) · 1,356 citations
- Hung-Ying Kao, Faculty h-index 40
Breast cancer (BC) is the most common cancer in women, with an estimated 276,500 new cases and 42,000 deaths in the US in 2020 . BCs can be further classified into three subtypes, based on their molecular identifications: Estrogen Rec
Notable: “Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase” (1997) · 1,251 citations
- William P. Schiemann, Faculty h-index 39
TGFβ & Cell Signaling Breast Cancer Metastasis & Recurrence Metastatic Dormancy Breast Cancer Stem Cells Epithelial-mesenchymal Transition Tumor Heterogeneity Noncoding RNAs Epigenome Research Projects Metastatic breast cancer
Notable: “Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivo” (1993) · 280 citations
- Focco van den Akker, Faculty h-index 37
The van den Akker lab focuses on structure-function and inhibitor design studies to combat antibiotic resistance.
Notable: “Crystal structure of cholera toxin B‐pentamer bound to receptor GM1 pentasaccharide” (1994) · 576 citations
- Vivien C. Yee, Faculty h-index 37
Dr. Yee's research interests span a variety of biomedically important proteins and enzymes with interesting mechanistic questions. Her lab has studied proteins involved in drug metabolism, neurodegenerative disorders, and antiviral defense
Notable: “Crystal structure of the human prion protein reveals a mechanism for oligomerization.” (2001) · 520 citations
- Boaz Tirosh, Faculty h-index 36
Survival of organisms requires adaptations to stress conditions. While acute stress conditions primarily direct cells to apoptosis, chronic conditions may irreversibly affect cell function and lead to pathologies, such as diabetes, inflamma
Notable: “Stimulation of Autophagy Improves Endoplasmic Reticulum Stress–Induced Diabetes” (2012) · 198 citations
- Jonatha Gott, Faculty h-index 25
My research focuses on RNA editing, the extraordinary process by which the primary sequence of specific RNAs are altered, leaving the genomic sequence unchanged. Such directed changes in RNA sequence occur in mammalian cells, viruses, plant
Notable: “FUNCTIONS AND MECHANISMS OF RNA EDITING” (2000) · 532 citations
- Joseph Luna, Faculty h-index 21
RNA-binding proteins regulate nearly every step of gene expression, and for many of them we have a reasonable catalog of what they bind. What remains poorly understood is how they are organized, how their activities are coordinated across c
Notable: “Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks” (2020) · 440 citations
- Kaixiang Cao, Faculty h-index 19
Epigenetic mechanisms play a central role in regulating cell fate determination processes during normal development and pathogenesis. Deciphering these mechanisms will shed light on developing novel therapies for treating human developmenta
Notable: “Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability” (2017) · 236 citations
- Leah Gates, Faculty h-index 15
The Gates lab studies the intersection between metabolism, chromatin, and gene regulation. We aim to discover how metabolite signaling to chromatin impacts cell and tissue function in health and disease. Research Projects The precise
Notable: “Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation” (2017) · 251 citations
- Mohammad Nazim, Faculty h-index 10
Defining the mechanistic interface between post-transcriptional RNA regulation and chromatin regulation that controls transcriptional and epigenetic programs underlying stem cell maintenance, cellular differentiation, tissue development, an
Notable: “Memory B Cell Responses to Vibrio cholerae O1 Lipopolysaccharide Are Associated with Protection against Infection from Household Contacts of Patients with Cholera in Bangladesh” (2012) · 81 citations
- Ryan Arvidson, Faculty h-index 7
My research interests lie in combining bioinformatics, molecular modeling, and cell biology techniques to understand structure-function relationships in the activation of G-protein coupled receptors. We use this approach to understand
Notable: “Parasitoid Jewel Wasp Mounts Multipronged Neurochemical Attack to Hijack a Host Brain” (2018) · 46 citations
- Susan Wang, Faculty h-index 5
Please note that Dr. Wang does not currently have an active lab and is not accepting any new students at this time. The radical SAM (S-adenosyl-L-methionine) enzyme superfamily was initially described in 2001. The members of this supe
Notable: “In Vitro Phosphinate Methylation by PhpK from Kitasatospora phosalacinea” (2011) · 71 citations
- Nathan Howell, Faculty
Please note that I do not have an active lab, and can only offer research and mentoring experiences connected to pedagogy. My previous research focused on the process of tRNA modification, where individual tRNA molecules are decorated with
- Wenjian Gan, Faculty
Genome sequencing revealed that there are approximately 20,000 protein-coding genes in the human genome. However, one million proteins with distinct functions are predicted in the human proteome. Post-translational modification (PTM) is a m
- Yi Zhang, Faculty
Selective autophagy, chromatin biology and epigenetics, and biomolecular condensates. Yi Zhang's Biography Research Information Research Interests Dr. Zhang’s research investigates topics at the interface of chemistry and bio
Roster/catalog compiled from the college’s public directory. Faculty counts are directory headcounts; the named list may be a subset. h-index shown only for ORCID-backed or high-confidence OpenAlex matches. Data as of 2026-07-02.